Notice: This article uses content directly taken from the Antagonists in Season Two article at the Vampire Diaries Wiki, and is licensed under the Creative Commons Attribution-Share Alike License.
| Character | Episodes | Appearances as Antagonist |
|---|---|---|
| Katherine Pierce | The Return, Memory Lane, Plan B, Masquerade, Know Thy Enemy | (5/18) |
| Damon Salvatore | Brave New World | (1/22) |
| Caroline Forbes | Brave New World | (1/20) |
| Mason Lockwood | Bad Moon Rising, Kill or Be Killed | (2/8) |
| Elijah Mikaelson | Rose, Katerina, The Sacrifice, The Dinner Party | (4/12) |
| Jules | By the Light of the Moon, The Descent, Daddy Issues, Crying Wolf | (4/6) |
| Niklaus Mikaelson | Know Thy Enemy, The Last Dance, Klaus, The Last Day, The Sun Also Rises, As I Lay Dying | (6/6) |
| Jonas Martin | The House Guest | (1/6) |