Notice: This article uses content directly taken from the Desiccation article at the Vampire Diaries Wiki, and is licensed under the Creative Commons Attribution-Share Alike License.
Desiccation is a weakness of immortals, Original vampires, vampires and hybrids that occurs to their bodies due to the lack of blood consumption. This is an automated process where their bodies dry out due to lack of any type of blood in their system.
In addition, this can also be achieved by bleeding out the body; preventing the heart from beating; spells/rituals, or siphoning the magic from vampires.