The relationship between the Supernatural Hunter, Jeremy Gilbert and the werewolf, Tyler Lockwood.
At first, both of them seemed to hate each other with a passion, as they both were rivals for Vicki Donovan's affection, and they were both in different social circles at school. Jeremy was a sophomore who was known to be a punk/druggie, while Tyler was a popular football player and a junior. Tyler generally preferred to ignore Jeremy, though Jeremy frequently confronted and antagonized Tyler to provoke him because he was unhappy about how Tyler treated Vicki. This typically ended in a fight between the two, because while Jeremy was often the person to start the fight, Tyler's hot-headed aggression (later learned to be caused by his werewolf heritage) would usually cause him to snap during these confrontations. However, as time went on and the two were both dragged into the supernatural drama in Mystic Falls, the two became allies and eventually close friends and housemates.